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Histamine Research in the New Millennium 9780444505828

Histamine Research in the New Millennium

Proceedings of the International Sendai Histamine Symposium: Which Was Held in Sendai, Japan, Betwee...

ISBN-10: 0444505822
ISBN-13: 9780444505828
PUBLISHER: Elsevier - Health Sciences Division
Also available at Amazon.com
Note: Not guaranteed to come with supplemental materials (access codes, CDs, DVDs)
Product Description: These proceedings cover the most recent advances on histamine research from basic science to clinical medicine. Histamine is an endogenous compound that is synthesized, stored, and released primarily by mast cells and after release exerts profound effects on many tissues and organs. It is one of the cellular mediators of the immediate hypersensitivity reaction and the acute inflammatory responses, as well as primary stimulant of gastric acid secretion. A central neurotransmitter role for histamine has been also established. Histamine research has been very dynamic since it discovery in 1910. Among recent important advances are: Generation of Histamine H1, H2, H3 receptors and histidine decraboxylase (HDC) knockout mice; Clarification of the constitutive activity of the H1, H2 and H3 receptors; Characterisation of H3 receptor isoforms with distinct signaling properties; and Characterisation and cloning of the H4 receptor.

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PUBLICATION DATE:
PAGES: 540
CATEGORY: Medical, Science
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